Nonsteroidal anti-inflammatory drugs are among the most common pain relief medications in the world. NSAIDS are known to reduce swelling and inflammation, dull pain as well as lowering fever. NSAIDS work on a chemical level. They block the effects of special enzymes; specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in making prostaglandins which are like hormones. By blocking the Cox enzymes, NSAIDS stop your body from making as many prostaglandins. This means less swelling and less pain, however, it also means that they have a negative effect on bone healing.